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Water → 4-[(2,4-Dichlorobenzoyl)amino]-2-chlorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2,4-Dichlorobenzyl chloride | HCID 7212 | — |
| 反応物 | 4-Amino-2-chlorobenzoic acid | HCID 17154 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[(2,4-Dichlorobenzoyl)amino]-2-chlorobenzoic acid | HCID 21836975 | — |
反応手順
To a stirred mixture of 5.19 g of 2-chloro-4-aminobenzoic acid in 150 ml of methylene chloride is added 7.86 g of N,N-diisopropylethylamine and 12.67 g of 2,4-dichlorobenzylchloride and stirring continued for 18 hours. Water is added to the filtrate and the organic layer dried with Na2 SO4 and concentrate in vacuo to give 13.68 g of the desired product, m.p. 171°-175° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733905 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-1da5671a1bbe46e789d3388e15982cfa |
| 出典メモ | uspto-grants-1998_03 |