Hydrochloric Acid → 5-Butylidene-3-[3-(imidazo[1,2-a]pyridin-8-yloxy)propyl]thiazolidine-2,4-dione hydrochloride
反応式
[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][O:14][C:15]2[C:16]3[N:17]([CH:21]=[CH:22][N:23]=3)[CH:18]=[CH:19][CH:20]=2)[C:6]1=[O:24])[CH2:2][CH2:3][CH3:4].[ClH:25]>CO>[ClH:25].[CH:1](=[C:5]1[S:9][C:8](=[O:10])[N:7]([CH2:11][CH2:12][CH2:13][O:14][C:15]2[C:16]3[N:17]([CH:21]=[CH:22][N:23]=3)[CH:18]=[CH:19][CH:20]=2)[C:6]1=[O:24])[CH2:2][CH2:3][CH3:4]参加物
4
実験手順
To a solution of 1.07 g (3.10 mmol) of 5-butylidene-3-[3-(imidazo[1,2-a]pyridin-8-yloxy)propyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.30 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.16 g (97.9%, light orange foamy substance) of the desired product.