Hydrogen chloride-ethyl acetate → 5-Pentylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione hydrochloride
反応式
[CH:1](=[C:6]1[S:10][C:9](=[O:11])[N:8]([CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[C:18]3[N:19]([CH:23]=[CH:24][N:25]=3)[CH:20]=[CH:21][CH:22]=2)[C:7]1=[O:26])[CH2:2][CH2:3][CH2:4][CH3:5].[ClH:27].C(OCC)(=O)C>CO>[ClH:27].[CH:1](=[C:6]1[S:10][C:9](=[O:11])[N:8]([CH2:12][CH2:13][CH2:14][CH2:15][O:16][C:17]2[C:18]3[N:19]([CH:23]=[CH:24][N:25]=3)[CH:20]=[CH:21][CH:22]=2)[C:7]1=[O:26])[CH2:2][CH2:3][CH2:4][CH3:5]参加物
4
実験手順
To a methanol solution of 0.934 g (2.5 mmol) of 5-pentylidene-3-[4-(imidazo[1,2-a]pyridin-8-yloxy)butyl]thiazolidine-2,4-dione, 0.625 ml of 4N hydrochloric acid-ethyl acetate was added, followed by stirring. After the solvent was distilled off, the residue was washed with ether to yield 1.03 g (quant., white solid) of the desired product.