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Water → 2-Bromo-4'-(methylsulfonyl)acetophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 4-Methylsulfonylacetophenone | HCID 82529 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-Bromo-4'-(methylsulfonyl)acetophenone | HCID 735823 | — |
反応手順
To a cooled (-5° C.) solution of 174 g of 4-(methylsulfonyl)acetophenone in 2.5 L of CHCl3 was added 20 mg of AlCl3, followed by a solution of 40 mL of Br2 in 300 mL CHCl3. The reaction mixture was then treated with 1.5 L of water and the CHCl3 was separated. The aqueous layer was extracted with 1 L of EtOAc. The combined extracts was dried over Na2SO4 and concentrated. The crude product was recystalized from 50/50 EtOAc/hexane to give 210 g of 2-bromo-1-(4-(methylsulfonyl)phenyl)ethanone as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05840746 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-e9da89578e424e6684ac304bc5885034 |
| 出典メモ | uspto-grants-1998_11 |