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Hydrochloric Acid → 2(5H)-Furanone, 3-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-(4-Fluorophenyl)acetic acid | HCID 9837 | — |
| 反応物 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 反応物 | 2-Bromo-4'-(methylsulfonyl)acetophenone | HCID 735823 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 2(5H)-Furanone, 3-(4-fluorophenyl)-4-[4-(methylsulfonyl)phenyl]- | HCID 10830394 | 68.2% |
反応手順
To the product of Step 1 (216 mg) dissolved in acetonitrile (4 mL) was added Et3N (0.26 mL), followed by 4-fluorophenylacetic acid (102 mg). After 1.5 h at room temperature 0.23 mL of DBU was added. The reaction mixture was stirred for another 45 min and then treated with 5 mL of 1N HCl. The product was extracted with EtOAc, dried over Na2 SO4 and concentrated. The residue was purified by flash chromatography (40% EtOAc in hexane) to yield 150 mg of the title compound as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05840746 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-9c1fef887e114a61b1c67230af1344c0 |
| 出典メモ | uspto-grants-1998_11 |