N-Allylaniline → HCID 14234331、化合物

HRID 35743

反応式

HRID 35743 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N+:15]([O-:17])[CH3:16])[CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[CH:4][CH:3]=1.[C:18]1([NH:24][CH2:25][CH:26]=[CH2:27])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:9][N:10]3[CH:14]=[CH:13][N:12]=[CH:11]3)[CH2:27][CH:26]([CH2:25][NH:24][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[O:17][N:15]2[CH3:16])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 68525N-AllylanilineHCID 727271741-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide

生成物 1

HCID 14234331HCID 14234331、化合物

実験手順

Derivative 3 (R1 =4-Cl, R2 =R3 =H) is obtained by a procedure similar to that described in Example 1 by reacting 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide (1: R1 =4-Cl) with N-phenyl-2-propen-1-amine (2: R2 =R3 =H). The product cis-/trans-diastereometric mixture is flash-chromatographed on neutral silica gel using chloroform-methanol (97:3 by volume) as eluent. Isomer A has a melting point of 159°-160° C. (ethyl acetate). Anal. Calcd for C21H23ClN4O: C, 65.87; H, 6.05; N, 14.63; Cl, 9.26. Found: C, 65.77; H, 6.20; N, 14.42; Cl, 9.48. Isomer B has a melting point of 172°-173° C. (ethyl acetate).

後処理

  1. customDerivative 3 (R1 =4-Cl, R2 =R3 =H) is obtained by a procedure similar to
  2. customThe product cis-/trans-diastereometric mixture is flash-chromatographed on neutral silica gel

出典と根拠

ORDレコード
ord-92bd0a9e9672482cb22f8354e7f581da
出典データセット
uspto-grants-1988_08
特許番号
US04767868

関連ノート

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