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Methyl Methanesulfonate → 4-Phenylamino-2-amino-1,6-dimethylpyrimidinium methanesulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Methanesulfonate | HCID 4156 | — |
| 反応物 | 2-Amino-4-phenylamino-6-methylpyrimidine | HCID 608203 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-Phenylamino-2-amino-1,6-dimethylpyrimidinium methanesulfonate | HCID 22394029 | — |
反応手順
Compound No. 46. A suspension of 4-phenylamino-2-amino-6-methylpyrimidine, Compound No. 45, (0.25 g) in ethanol (4 mL) was treated with methyl methanesulfonate (0.090 g) and heated at reflux for 5 days. Additional methyl methanesulfonate (0.090 g) was added and the mixture refluxed another 2 days. Concentration and recrystallization from a mixture of methanol, ethyl acetate, and tert-butyl ethyl ether gave 0.10 g of 4-phenylamino-2-amino-1,6-dimethylpyrimidinium methanesulfonate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05840893 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-f24f54d65ef442c7b58e0628f384ffa6 |
| 出典メモ | uspto-grants-1998_11 |