関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | Methane | HCID 297 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Rubitecan | HCID 472335 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 9-Aminocamptothecin | HCID 72402 | 79.6% |
反応手順
9-nitro camptothecin (3.4 g) was dissolved in distilled DMF (100 ml). Palladium acetate (0.08 g), formic acid (0.95 ml), and triethylamine (3.5 ml) were added. The solution was heated to 80° C., and the heating was continued for 1 hour. DMF (200 ml) and charcoal were added to the reaction mixture, and the stirring was continued for 0.5 hours at 80° C. The mixture was filtered hot through a celite filter aid, and the filtrate was concentrated to small volume. The precipitated orange solid was collected by filtration to yield 2.5 g of 9-amino camptothecin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05840899 |
|---|
| 出典データセット | uspto-grants-1998_11 |
|---|
| ORD ID | ord-09dddc8345924d6c9f07196455a0bc84 |
|---|
| 出典メモ | uspto-grants-1998_11 |
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