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Hydrochloric Acid → 2,3,4,5-Tetrafluorobenzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,2,3,4-Tetrafluoro-5-(trichloromethyl)benzene | HCID 15346007 | — |
| 反応物 | HCID 178418416 | HCID 178418416 | — |
| 触媒 | Iron chloride (FeCl3) | HCID 24380 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 生成物 | 2,3,4,5-Tetrafluorobenzoyl chloride | HCID 2733689 | — |
反応手順
268 g of 2,3,4,5-tetrafluorobenzotrichloride were placed in a stirred apparatus and 5.3 [lacuna] of iron(III) chloride were added, 45 g of formic acid (98-100%) were pumped in over 8 hours at 60° C. Vigorous gas development (carbon monoxide, hydrogen chloride) began immediately. The gas stream was fed to an absorption tower via a cooler. After addition was complete, the mixture was stirred until the end of gas development. The product was then distilled. 195 g of 2,3,4,5-tetrafluorobenzoyl chloride were obtained (91.5% of theory); b.p.: 70°-72° C./20 mbar, nD25 : 1.4773.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05840975 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-7903e75866d04d5fb98f14728c9684aa |
| 出典メモ | uspto-grants-1998_11 |