Hydrogen Peroxide → (1R,2R)-2-bromo-2,3-dihydro-1H-inden-1-ol

温度

20 °C

100 ml of water and 0.70 g of Triton X-100 were put into a 300-ml 4-mouthed flask, and mixed as 80 ml of ortho-dichlorobenzene and 60.0 g of indene (95 wt %; 0.491 mol) were added. At 20° C., 41.54 g of bromine (0.259 mol) was added with strong stirring and air cooling over approximately 5 minutes. After dropwise addition the temperature of the reaction mixture became 52° C. After mixing at 60° C. for 13 hours, 23.8 g of hydrogen peroxide (35 wt %; 0.245 mol) was added dropwise at the same temperature, requiring 3 hours, followed by mixing for a further 3 hours at 60° C. and then separation into an aqueous layer and a slurry layer. The aqueous layer was extracted with 120 ml of ortho-dichlorobenzene, and the extract layer was bulked with the earlier slurry layer. The warm slurry layer was cooled gradually to 20° C. under stirring, the crystals which came down were isolated by centrifugation and washed with 30 ml of ortho-dichlorobenzene. The wet crystals were dried at 65°-70° C. under decreased pressure to obtain 72.18 g of white crystals of trans-2-bromoindan-1-ol (yield 69.0%).

1. additionwere added
2. temperatureair cooling over approximately 5 minutes
3. additionAfter dropwise addition the temperature of the reaction mixture
4. custombecame 52° C
5. additionAfter mixing at 60° C. for 13 hours
6. additionby mixing for a further 3 hours at 60° C.
7. customseparation into an aqueous layer
8. extractionThe aqueous layer was extracted with 120 ml of ortho-dichlorobenzene
9. stirringunder stirring
10. customthe crystals which came down were isolated by centrifugation
11. washwashed with 30 ml of ortho-dichlorobenzene
12. customThe wet crystals were dried at 65°-70° C.

ORDレコード

ord-27dd2504458f46eb87c14b0097ac52a5

出典データセット

uspto-grants-1998_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05841000