Potassium Hydroxide → 1-(1-Bromovinyl)-3-chlorobenzene
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([Br:11])[CH2:9]Br)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[C:8]([Br:11])=[CH2:9]参加物
4
実験手順
In 50 ml of ethanol was suspended 20.8 g (69.7 mmol) of 3-chloro-α,β-dibromoethylbenzene. To the suspension was added 100 ml of an ethanol solution containing 5.8 g (103.4 mmol) of potassium hydroxide at room temperature, and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was poured into 150 ml of ice-water and extracted with 300 ml of diethyl ether. The extract was dried over anhydrous sodium sulfate and concentrated to give 15.0 g (purity: 99%) of 3-chloro-α-bromostyrene. 1H-NMR (CDC13, 8): 5.82 (1H, d), 6.14 (1H, d), 7.26-7.33 (2H, m), 7.45-7.49 (1H, m), 7.57-7.58 (1H, m)
後処理
- customAfter completion of the reaction
- extractionextracted with 300 ml of diethyl ether
- dry with materialThe extract was dried over anhydrous sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-99ca9ae8663040e6a01e6cd801436cbc
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05841004
反応ノート
読み込み中…