2-chlorothiophene-3-carboxylic Acid → 5-Bromo-2-chlorothiophene-3-carboxylic acid

HRID 357797ノート

反応式

HRID 357797 の反応式
[Cl:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([OH:9])=[O:8].C1C=C[NH+]=CC=1.[Br:16][Br-]Br>C(O)(=O)C>[Br:16][C:4]1[S:3][C:2]([Cl:1])=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=1

参加物

3

反応物 1

HCID 36627282-chlorothiophene-3-carboxylic Acid

生成物 1

HCID 223971905-Bromo-2-chlorothiophene-3-carboxylic acid収率 77.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
40 °C

実験手順

A mixture of 2-chloro-3-thiophenecarboxylic acid (2.44 g), pyridinium bromide perbromide (5.33 g) and acetic acid (15 ml) was stirred at 40° C. for 4 hours and poured into ice-water. Precipitated crystals were collected by filtration, dissolved in ethyl acetate and dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give 5-bromo-2-chloro-3-thiophenecarboxylic acid (2.81 g) as crystals.

後処理

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. dissolutiondissolved in ethyl acetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationThe solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-572152529d804ea3aea13e865119883c
出典データセット
uspto-grants-1998_11
特許番号
US05840917

反応ノート

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