2-Butanone, 3-bromo- → 6-Methyl-8-phenylmethoxy-2,3-dimethylimidazo[1,2-b]pyridazine

HRID 358023

反応式

HRID 358023 の反応式
[NH2:1][C:2]1[N:3]=[N:4][C:5]([CH3:16])=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.Br[CH:18]([C:20](=O)[CH3:21])[CH3:19]>CO>[CH3:16][C:5]1[CH:6]=[C:7]([O:8][CH2:9][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:2]2[N:3]([C:18]([CH3:19])=[C:20]([CH3:21])[N:1]=2)[N:4]=1

参加物

4

反応物 2

HCID 131422-Butanone, 3-bromo-HCID 155919113-Amino-6-methyl-4-phenylmethoxypyridazine

生成物 1

HCID 155919126-Methyl-8-phenylmethoxy-2,3-dimethylimidazo[1,2-b]pyridazine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of (0.01 mole) 3-amino-6-methyl-4-phenylmethoxypyridazine, [prepared following the methodology of Becket, et al. J. Pract. Chem., 311, 285(1969) and references cited therein], and (0.012 mole) 2-bromo-3-butanone in methanol is heated for 24 hours in a bath maintained at 100°. The mixture is cooled to room temperature and partitioned between aqueous sodium bicarbonate and methylene chloride. The layers are separated and the aqueous phase extracted with methylene chloride. The organic extracts are combined and dried over anhydrous sodium sulfate. The solvent is removed under reduced pressure to give 6-methyl-8-phenylmethoxy-2,3-dimethylimidazo[1,2-b]pyridazine.

後処理

  1. custom[prepared
  2. temperaturemaintained at 100°
  3. custompartitioned between aqueous sodium bicarbonate and methylene chloride
  4. customThe layers are separated
  5. extractionthe aqueous phase extracted with methylene chloride
  6. dry with materialdried over anhydrous sodium sulfate
  7. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-1717a85a15664a429084898fa46e5458
出典データセット
uspto-grants-1984_08
特許番号
US04464372

関連ノート

読み込み中…