Aniline → 4-Anilino-7-trifluoromethylquinazoline

HRID 358031

反応式

HRID 358031 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(O)C>[NH:16]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 2

HCID 6115AnilineHCID 128067424-Chloro-7-(trifluoromethyl)quinazoline

生成物 1

HCID 128067734-Anilino-7-trifluoromethylquinazoline収率 60%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.5 g of 4-chloro-7-trifluoromethylquinazoline were dissolved in 10 ml of ethanol, and 1.0 g of aniline was added to the solution. Reaction occurred violently and the reaction mixture solidified immediately. After cooling, the solidified product was collected and washed with ethanol. The resulting crystals were pulverized and added to a dilute aqueous solution of sodium hydroxide. Insolubles were filtered off and recrystallized from ethanol to give 1.7 g (yield 60%) of the desired Compound No. 17 in the form of colourless plates melting at 230°-232° C.

後処理

  1. customReaction
  2. temperatureAfter cooling
  3. customthe solidified product was collected
  4. washwashed with ethanol
  5. additionadded to a dilute aqueous solution of sodium hydroxide
  6. filtrationInsolubles were filtered off
  7. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-286f2e10af6c4eb48b67a76a2bfad034
出典データセット
uspto-grants-1984_08
特許番号
US04464375

関連ノート

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