N-Methylaniline → 4-(N-Methylanilino)-7-trifluoromethylquinazoline

HRID 358034

反応式

HRID 358034 の反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:16][NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[CH3:16][N:17]([C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

4

反応物 2

HCID 7515N-MethylanilineHCID 128067424-Chloro-7-(trifluoromethyl)quinazoline

生成物 1

HCID 127745164-(N-Methylanilino)-7-trifluoromethylquinazoline収率 46%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.5 g of 4-chloro-7-trifluoromethylquinazoline and 1.2 g of N-methylaniline were added, in turn, to 5 ml of ethanol, and then the mixture was heated until it became a homogeneous solution. At the end of this time, the ethanol was distilled off and the residual crystals were recrystallized from a 9:1 by volume mixture of ethanol and water, to give 1.4 g (yield 46%) of the desired Compound No. 73 in the form of colourless granules melting at 135°-137° C.

後処理

  1. temperaturethe mixture was heated until it
  2. distillationAt the end of this time, the ethanol was distilled off
  3. customthe residual crystals were recrystallized from a 9:1 by volume mixture of ethanol and water

出典と根拠

ORDレコード
ord-756e41a2ab114a1999c1a1e86ce969d1
出典データセット
uspto-grants-1984_08
特許番号
US04464375

関連ノート

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