Isoniazid → HCID 20450003、化合物
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=S)[CH2:9][CH:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[F:19])[C:6]=2[CH:20]=1.[C:21]([NH:29][NH2:30])(=O)[C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1>C(O)CCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:21]([C:22]4[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=4)=[N:29][N:30]=[C:10]3[CH2:9][CH:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[F:19])[C:6]=2[CH:20]=1参加物
4
実験手順
6 g of 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1-benzazepine-2-thione and 27 g of isonicotinic acid hydrazide are dissolved together in 360 ml of n-butanol and heated to boiling under reflux for 24 hours. After evaporation of the resulting solution in vacuo, the residue is partitioned between toluene and water. The toluene phase is concentrated to about 100 ml. The precipitated crystals are filtered off and recrystallized from benzene. There is obtained 8-chloro-6-(2-fluorophenyl)-1-(4-pyridyl)-4H-s-triazolo[4,3-a][1]benzazepine of melting point 198°-200°.