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Dicyclohexylcarbodiimide → HCID 15602370、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | N-Hydroxysuccinimide | HCID 80170 | — |
| 反応物 | N2-((tert-Butoxy)carbonyl)-L-asparagine | HCID 82035 | — |
| 反応物 | Benzyl glycinate | HCID 409140 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | HCID 15602370 | HCID 15602370 | — |
反応手順
58 g BocAsnOH (0.25 moles) and 29 g HOSu are dissolved in 250 ml DMF and cooled to -20°. 52 g DCC dissolved in 250 ml DMF is added. After 4 hours stirring at room temperature 85 g GlyOBzl, pTos and 35 ml TEA is added. After stirring overnight the DCU i filtered off, DMF removed in vacuo on a Rotavap, and the resulting oil dissolved in EtAc. After extraction with sat. NaCl, sat. NaHCO3, and 10% citric acid, the solvent is dried with Na2SO4 and evaporated. The resulting crystalline ma is dried in a desiccator. Yield: 64 g (67%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411942 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-031dd53497104afebe992320752ede0e |
| 出典メモ | uspto-grants-1995_05 |