関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Methylmorpholine | HCID 7972 | — |
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| 反応物 | Benzyl 2-aminoacetate hydrochloride | HCID 11701227 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | BOC-Leu-Gly-OBzl | HCID 13242213 | — |
反応手順
102.2 g (442 mmoles) Boc-Leu-OH, 98.1 g (485 mmoles) Gly-OBzl.HCl and 55.9 g (478 mmoles HONSu were dissolved in 760 ml dichloromethane added 54 ml N-methylmorpholine. Cooling to 4° C. and addition of a cold solution (4° C.) of 100.1 g (485 mmoles) DCC in 190 ml dichloromethane. The stirring was kept for one day at 4° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05411942 |
|---|
| 出典データセット | uspto-grants-1995_05 |
|---|
| ORD ID | ord-f4c446e5a0cc46029e9dc6fd31419af5 |
|---|
| 出典メモ | uspto-grants-1995_05 |
|---|
