Methanimidic acid, N-phenyl-, ethyl ester → HCID 178482101、化合物

HRID 358258

反応式

HRID 358258 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[CH:10][NH:11][CH:12]=2)=[CH:4][CH:3]=1.[C:13]1([N:19]=[CH:20]OCC)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CC(C)=O>[C:13]1([NH:19][CH:20]=[N:1][C:2]2[CH:3]=[CH:4][C:5]([C:8]3[N:9]=[CH:10][NH:11][CH:12]=3)=[CH:6][CH:7]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 111236Methanimidic acid, N-phenyl-, ethyl esterHCID 178507418HCID 178507418、化合物

生成物 1

HCID 178482101HCID 178482101、化合物収率 56.9%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Five grams of 4-(4-aminophenyl)-1-H-imidazole were added to a solution of 4.6 gm of ethyl N-phenyl-formimidate [Org. Synth., 35, 65 (1965)] in 25 ml of acetone. After stirring for four hours at room temperature, the solid that separated was filtered and dried under vacuum. The product was treated with acetone and acidified with glacial acetic acid. N-Phenyl-N'-[4-(imidazol-4-yl]-formamidine crystallized as acetate salt which was filtered to give 4.6 gm of the desired product.

後処理

  1. customthe solid that separated
  2. filtrationwas filtered
  3. customdried under vacuum
  4. additionThe product was treated with acetone
  5. customN-Phenyl-N'-[4-(imidazol-4-yl]-formamidine crystallized as acetate salt which
  6. filtrationwas filtered

出典と根拠

ORDレコード
ord-699e0aeb59e647b5813b7ec3e468f229
出典データセット
uspto-grants-1984_08
特許番号
US04465841

関連ノート

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