Ethyl formate → N-[2-(morpholin-4-yl)ethyl]formamide
反応式
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1.[CH:10](OCC)=[O:11]>>[CH:10]([NH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][O:7][CH2:6][CH2:5]1)=[O:11]参加物
3
実験手順
The procedure of B. V. Cheney et al. [J. Med. Chem., 28, 1853-1864 (1985)) was used. A solution of 4-(2-aminoethyl)morpholine (1.00 g, 76.8 mmol) and ethyl formate (213 mL, 2640 mmol) was refluxed overnight under an atmosphere of nitrogen. Vacuum distillation gave 1.46 g (100% yield) of a clear, colorless liquid (bP0.3 18°-120° C.). The 1H NMR spectral data were consistent with the structure of the title compound.
後処理
- distillationVacuum distillation
- customgave 1.46 g (100% yield) of a clear, colorless liquid (bP0.3 18°-120° C.)
出典と根拠
- ORDレコード
- ord-465544de9a6e46c0ad14764ed8196d18
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05411959
反応ノート
読み込み中…