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Sodium hydride → Quinazoline, 4-(2-(4-chlorophenyl)ethoxy)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | p-Chlorophenethylic alcohol | HCID 74647 | — |
| 反応物 | 4-Chloroquinazoline | HCID 78864 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Quinazoline, 4-(2-(4-chlorophenyl)ethoxy)- | HCID 164154 | 2.4% |
反応手順
To a solution of 1.1 g of sodium hydride in 50 ml of DMF was added 3.4 g of 2-(4-chlorophenyl)ethanol, and the mixture was stirred at room temperature for one hour. Then 3.6 g of 4-chloroquinazoline in 20 ml of DMF were added, and the mixture was stirred overnight. The mixture was then poured into a mixture of ice in water. Solid was collected and recrystallized from pentane giving 0.149 g of the title product. Yield: 2.4%. M.P. 57°-58° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411963 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-ca27611c751f4bdab9cd7b26cf35749a |
| 出典メモ | uspto-grants-1995_05 |