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Methyl Isocyanate → 1-(Methylcarbamoyl)-3-[(4-chlorophenyl)thio]-azacycloheptan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 反応物 | Di-n-butyldilauryltin | HCID 9809426 | — |
| 反応物 | 3-[(4-Chlorophenyl)thio]-azacycloheptan-2-one | HCID 13268904 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-(Methylcarbamoyl)-3-[(4-chlorophenyl)thio]-azacycloheptan-2-one | HCID 20448003 | — |
反応手順
25.6 g (0.1 mol) of 3-[(4-chlorophenyl)thio]-azacycloheptan-2-one together with 5.7 g (0.1 mol) of methyl isocyanate and 100 mg of dibutyl-tin dilaurate in 150 ml of absolute toluene are boiled under reflux for 5 hours. After the mixture has cooled, the solvent is stripped off in vacuo, and the oily residue is used for further reactions.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04468392 |
| 出典データセット | uspto-grants-1984_08 |
| ORD ID | ord-7067370980904d529ab71b7ad55b6b99 |
| 出典メモ | uspto-grants-1984_08 |