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Sodium hydride → 8-Fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Methylphenethyl alcohol | HCID 95294 | — |
| 反応物 | 4-Chloro-8-fluoroquinazoline | HCID 19939133 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-Fluoro-4-[2-(4-methylphenyl)ethoxy]quinazoline | HCID 19939085 | — |
反応手順
To a mixture of 0.6 g of sodium hydride (50%, suspension in oil) and 2 g of 4-chloro-8-fluoroquinazoline in 20 ml of DMF was added 1.64 g of 2-(4-methylphenyl)ethanol, and the mixture was stirred for one hour. Then the mixture was poured into ice water. The solid was collected by filtration. Yield: 0.7 g (20.5%). M.P. 72°-74° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411963 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-25910daf5c584d5dabadded8b8a7a749 |
| 出典メモ | uspto-grants-1995_05 |