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3-Amino-5-methylisoxazole → 6-Benzyl-5,6-dihydro-4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Amino-5-methylisoxazole | HCID 66172 | — |
| 反応物 | Acetone diisopropyl ether | HCID 22221350 | — |
| 反応物 | methyl 6-benzyl-5,6-dihydro-4-hydroxy-2-methyl-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxylate | HCID 54719673 | — |
| 反応物 | Diisopropyl ether formic acid | HCID 86748651 | — |
| 生成物 | 6-Benzyl-5,6-dihydro-4-hydroxy-2-methyl-N-(5-methyl-3-isoxazolyl)-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxamide | HCID 54719674 | 59% |
反応手順
The synthesis is effected analogously to Example 1 using in each case 1 equivalent of methyl 6-benzyl-5,6-dihydro-4-hydroxy-2-methyl-1,1-dioxo-2H-1,2,6-thiadiazine-3-carboxylate and 3-amino-5-methylisoxazole. Chromatography over silica gel using a mixture of diisopropyl ether/formic acid=100/1 or recrystallisation from a diisopropyl ether/acetone mixture gives the title compound in a yield of 59%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411955 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-60ff78ad634e4d849b92503a1c955644 |
| 出典メモ | uspto-grants-1995_05 |