Pyridine, 2-methyl-4-nitro-, 1-oxide → HCID 178428516、化合物
反応式
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][N+:3]=1[O-:11]>CO.[Pd].C>[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][N+:3]=1[O-:11]参加物
4
実験手順
4 g of 2-methyl-4-nitropyridine-N-oxide were dissolved in 90 ml of methanol and reduced with 1.2 g of 10% Pd/charcoal and H2. The catalyst was filtered off and the filtrate rotated in. The residue was boiled with 200 ml of ethyl acetate, filtered hot and the filtrate was mixed with 100 ml of hexane. The crystals precipitated after cooling the solution was sucked off, washed and dried. 3.1 g of 2-methyl-4-aminopyridine-N-oxide were obtained.
後処理
- filtrationThe catalyst was filtered off
- filtrationfiltered hot
- additionthe filtrate was mixed with 100 ml of hexane
- customThe crystals precipitated
- temperatureafter cooling the solution
- washwashed
- customdried
出典と根拠
- ORDレコード
- ord-89149ce471274d54bb86c6416d849b1f
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US04997835
反応ノート
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