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2-Butenoic acid, 3-amino-, ethyl ester → Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Butenoic acid, 3-amino-, ethyl ester | HCID 95308 | — |
| 反応物 | Cinnamaldehyde | HCID 637511 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Piperidine | HCID 8082 | — |
| 生成物 | Ethyl 2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxylate | HCID 14652661 | 72.3% |
反応手順
(E)-3-Phenyl-2-propenal (13.8 ml, 0.11 mol) and ethyl 3-amino-2-butenoate (12.9 g, 0.1 mol) were dissolved in 150 ml of absolute ethanol containing 0.5 ml of piperidine. The mixture was heated under reflux for 18 hours followed by removal of the solvent under vacuum to yield 17.6 g of ethyl 1,4-dihydro-2-methyl-4-phenyl-3-pyridinecarboxylate as a brown viscous oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04997837 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-42e9defa45784b289909b967b73d63bc |
| 出典メモ | uspto-grants-1991_03 |