Methyl 7-phthalimidohept-5-ynoate → 7-Phthalimidohept-5-ynoic Acid

HRID 358619ノート

反応式

HRID 358619 の反応式
[C:1]1(=[O:21])[N:5]([CH2:6][C:7]#[C:8][CH2:9][CH2:10][CH2:11][C:12]([O:14]C)=[O:13])[C:4](=[O:16])[C:3]2=[CH:17][CH:18]=[CH:19][CH:20]=[C:2]12>Cl.CC(C)=O.O>[C:4]1(=[O:16])[N:5]([CH2:6][C:7]#[C:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:1](=[O:21])[C:2]2=[CH:20][CH:19]=[CH:18][CH:17]=[C:3]12

参加物

5

反応物 1

HCID 20066955Methyl 7-phthalimidohept-5-ynoate

生成物 1

HCID 154705147-Phthalimidohept-5-ynoic Acid収率 81.2%

試薬・触媒・溶媒 3

HCID 180Acetone溶媒HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒2 回

実験手順

Methyl 7-phthalimidohept-5-ynoate (1.45 g) was dissolved in a mixture of concentrated hydrochloric acid (7.3 ml), acetone (30 ml) and water (14.6 ml) and the resulting solution was heated at reflux for 3.5 hours. The solution was cooled and then poured into water (175 ml). The precipitate was collected by filtration and recrystallised from ethanol-water to give the title compound (1.12 g) m.p. 120°-122° C.

後処理

  1. temperaturethe resulting solution was heated
  2. temperatureat reflux for 3.5 hours
  3. temperatureThe solution was cooled
  4. filtrationThe precipitate was collected by filtration
  5. customrecrystallised from ethanol-water

出典と根拠

ORDレコード
ord-d5c0e32b8e5c4f339814a1b6d66005ad
出典データセット
uspto-grants-1991_03
特許番号
US04997847

反応ノート

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