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3,4-dihydro-2H-pyran → 2-(5-Bromopentyloxy)tetrahydro-2H-pyran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | 1-Pentanol, 5-bromo- | HCID 118709 | — |
| 触媒 | Phosphorus oxychloride | HCID 24813 | — |
| 生成物 | 2-(5-Bromopentyloxy)tetrahydro-2H-pyran | HCID 2786933 | 52% |
反応手順
Three drops of phosphoryl chloride were added to a stirred mixture of 5-bromopentanol (34.3 g, 205 mmol) and dihydropyran (19.0 g, 226 mmol). After standing for one hour, the mixture was fractionated. Yield 34.7 g, b.p. 102° C. (0.2 bar). Chromatography on alumina eluted with petroleum ether gave the pure title compound (25.1 g, 52% of theory) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04997847 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-fd69aa4689b64c6c9ad67cbdf7ab837b |
| 出典メモ | uspto-grants-1991_03 |