Piperidine → 4(1H)-Quinolinone, 3-hydroxy-1-methyl-

HRID 358656ノート

反応式

HRID 358656 の反応式
C([O:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH3:21])[CH:11]=1)(=O)C1C=CC=CC=1.N1CCCCC1>ClCCl>[OH:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]([CH3:21])[CH:11]=1

参加物

4

反応物 2

HCID 8082Piperidine2 回HCID 539443861-Methyl-4-oxo-1,4-dihydroquinol-3-yl benzoate

生成物 1

HCID 5900784(1H)-Quinolinone, 3-hydroxy-1-methyl-

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1-methyl-4-oxo-1,4-dihydroquinol-3-yl benzoate (45 g), piperidine (16.9 ml) and dichloromethane (700 ml) was stirred for 3 days at ambient temperature under nitrogen. A further portion of piperidine (3 ml) was added and the stirring continued for 1 day. The solvent was removed by distillation at 50° and the residue was triturated with diethyl ether (300 ml). The resultant solid was collected by filtration and washed with diethyl ether (2×100 ml) to give 3-hydroxy-1-methyl-4-quinolone, m.p. 243°-246°.

後処理

  1. waitthe stirring continued for 1 day
  2. customThe solvent was removed by distillation at 50°
  3. customthe residue was triturated with diethyl ether (300 ml)
  4. filtrationThe resultant solid was collected by filtration
  5. washwashed with diethyl ether (2×100 ml)

出典と根拠

ORDレコード
ord-30ebf9365b414b4e96b9d8680104048a
出典データセット
uspto-grants-1991_03
特許番号
US04997840

反応ノート

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