Water → N-[2-(Chloroacetyl)-4-fluorophenyl]-N-methylformamide
反応式
S(Cl)([Cl:4])(=O)=O.[C:6]([C:9]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:10]=1[N:11]([CH3:14])[CH:12]=[O:13])(=[O:8])[CH3:7].O>ClCCl>[Cl:4][CH2:7][C:6]([C:9]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:10]=1[N:11]([CH3:14])[CH:12]=[O:13])=[O:8]参加物
5
実験手順
A solution of sulphuryl chloride (3.2 ml) in dichloromethane (20 ml) was added dropwise over a period of 10 minutes to the solution of 2'-acetyl-4'-fluoro-N-methylformanilide at 0° under a nitrogen atmosphere and the mixture stored overnight at 0 to 5°. Water (25 ml) was added whilst maintaining the temperature below 1 0°. The dichloromethane layer was separated, washed with water (1 25 ml) and dried over magnesium sulphate to give a solution of 2'-(2-chloroacetyl)-4'-fluoro-N-methylformanilide.
後処理
- temperaturewhilst maintaining the temperature below 1 0°
- customThe dichloromethane layer was separated
- washwashed with water (1 25 ml)
- dry with materialdried over magnesium sulphate
出典と根拠
- ORDレコード
- ord-383194421a11471cb4e3f900565de519
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US04997840
反応ノート
読み込み中…