Piperidine → 6-Fluoro-3-hydroxy-1-methyl-4-quinolone

HRID 358680ノート

反応式

HRID 358680 の反応式
C([O:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([F:21])[CH:17]=2)[N:12]([CH3:22])[CH:11]=1)(=O)C1C=CC=CC=1.N1CCCCC1>ClCCl>[F:21][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]([CH3:22])[CH:11]=[C:10]([OH:9])[C:19]2=[O:20]

参加物

4

反応物 2

HCID 8082PiperidineHCID 542187166-Fluoro-1-methyl-4-oxo-1,4-dihydroquinol-3-yl benzoate

生成物 1

HCID 231280776-Fluoro-3-hydroxy-1-methyl-4-quinolone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 6-fluoro-1 -methyl-4-oxo-1 ,4-dihydro-quinol-3-yl benzoate (1.90 g), piperidine (0.9 ml) and dry dichloromethane (50 ml) was stirred under nitrogen for 24 hours at ambient temperature. The solvent was removed by distillation and the residue triturated with diethyl ether (100 ml). The resultant solid was collected by filtration to give the novel compound 6-fluoro-3-hydroxy-1-methyl-4-quinolone, m.pp. 104°-106°.

後処理

  1. customThe solvent was removed by distillation
  2. customthe residue triturated with diethyl ether (100 ml)
  3. filtrationThe resultant solid was collected by filtration

出典と根拠

ORDレコード
ord-21bd8084f693488d94d2a08d4c529084
出典データセット
uspto-grants-1991_03
特許番号
US04997840

反応ノート

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