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2-Phenylbutyric Acid → Methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Phenylbutyric Acid | HCID 7012 | — |
| 反応物 | 2,3,5-Trimethyl-6-nitro-1H-indole | HCID 609328 | — |
| 反応物 | Methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate | HCID 19744303 | — |
| 生成物 | Methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]-benzoate | HCID 19744308 | 32% |
反応手順
Similarly, starting from methyl 4-(6-amino-2,3,5-trimethylindol-1-ylmethyl)-3-methoxybenzoate (itself obtained using the procedures described for A in Example 1 but starting from 2,3,5-trimethyl-6-nitroindole [G]) and 2-phenylbutyric acid, there was obtained methyl 3-methoxy-4-[2,3,5-trimethyl-6-(2-phenylbutanamido)indol-1-ylmethyl]benzoate [Example 83] in 32% yield as a white solid; partial NMR: 0.9 (t,3H,CH2CH3), 1.2 (m,2H, CH2CH3), 3.4 (t,1H,CHPh), 7.3 (s,5H,Ph).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04997844 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-dbd3a55b4fd647e29aeb556cbbd9f713 |
| 出典メモ | uspto-grants-1991_03 |