Hydrochloric Acid → trans-3-Amino-4-methoxypyrrolidine dihydrochloride

HRID 358900ノート

反応式

HRID 358900 の反応式
[ClH:1].[NH2:2][CH:3]1[CH:7]([O:8][CH3:9])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1>C(O)C>[ClH:1].[ClH:1].[NH2:2][C@H:3]1[C@H:7]([O:8][CH3:9])[CH2:6][NH:5][CH2:4]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 20067140tert-Butyl 3-amino-4-methoxypyrrolidine-1-carboxylate

生成物 1

HCID 67925434trans-3-Amino-4-methoxypyrrolidine dihydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

6.3 ml of 6N aqueous hydrochloric acid were added to a solution of 0.4 g (0.0019 mole) of 3-amino-1-t-butoxycarbonyl-4-methoxypyrrolidine [prepared as described in Step (3) above] dissolved in 20 ml of ethanol, and the mixture was heated under reflux for 1.5 hours, after which the solvent was removed by evaporation under reduced pressure. The residue was washed with a 1:9 by volume mixture of ethanol and ethyl acetate to give 0.34 g of trans-3-amino-4-methoxypyrrolidine dihydrochloride as a colorless powder, melting at 248°~258° C. (with decomposition).

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1.5 hours
  3. customafter which the solvent was removed by evaporation under reduced pressure
  4. washThe residue was washed with a 1:9 by volume mixture of ethanol and ethyl acetate

出典と根拠

ORDレコード
ord-995b5ec61da5453f84f27d08bd551762
出典データセット
uspto-grants-1991_03
特許番号
US04997943

反応ノート

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