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m-Chloroperbenzoic acid → 6-Methylpyridine-3-carbonitrile 1-oxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 反応物 | 6-Methylpyridine-3-carbonitrile | HCID 281995 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-Methylpyridine-3-carbonitrile 1-oxide | HCID 19818671 | — |
反応手順
A mixture of 6-methylnicotinonitrile (4.15 g) and 3-chloroperbenzoic acid (8.3 g) in dichloromethane (200 ml) was stirred under an argon atomosphere at room temperature for 16h. The dichloromethane was evaporated under reduced pressure and the residue purified by flash column chromatography on silica (K60), using ethyl acetate and then methanol: dichloromethane (1:9 by volume) as eluting solvent to give 5-cyano-2-methylpyridine-1-oxide, mp 133.5°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04999364 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-a78378da87434bf7a8573388e582ea7e |
| 出典メモ | uspto-grants-1991_03 |