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Dimethylformamide → 4-(1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Nitrourea | HCID 62372 | — |
| 反応物 | 1-phenyl-3-(1-piperazinyl)-1H-indazole | HCID 9795644 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide | HCID 15117099 | 57% |
反応手順
A mixture of 4.9 g of 1-phenyl-3-(1-piperazinyl)-1H-indazole, 5.1 g of nitrourea, and 80 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized from ethyl acetate (2×) to yield 3.1 g (57%) of 4-(1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide, m.p. 151°-153°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04999356 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-e75dcb048f51472e84f9ab3bd0a92f90 |
| 出典メモ | uspto-grants-1991_03 |