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Dimethylformamide → 4-[1-(4-fluorophenyl)-1H-indazol-3-yl]-1-piperazine carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Nitrourea | HCID 62372 | — |
| 反応物 | 1-(4-fluorophenyl)-3-(1-piperazinyl)-1H-indazole | HCID 15117082 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-[1-(4-fluorophenyl)-1H-indazol-3-yl]-1-piperazine carboxamide | HCID 15117100 | 47.2% |
反応手順
A mixture of 5.0 g of 1-(4-fluorophenyl)-3-(1-piperazinyl)-1H-indazole, 5.1 g of nitrourea, and 80 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized from ethyl acetate (2×) to yield 2.7 g (47%) of 4-[1-(4-fluorophenyl)-1H-indazol-3-yl]-1-piperazine carboxamide, m.p. 148°-150°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04999356 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-6046f9ba4ad845dfa8c513c688871ada |
| 出典メモ | uspto-grants-1991_03 |