Dimethylformamide → 1-Piperazinecarboxamide

HRID 359035

反応式

HRID 359035 の反応式
[N:1]1([C:7]2C3C(=CC=CC=3)N(C3C=CC(C(F)(F)F)=CC=3)[N:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[N+](NC(N)=O)([O-])=[O:27].CN(C)C=O>O>[N:1]1([C:7]([NH2:8])=[O:27])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 62372NitroureaHCID 15117089HCID 15117089、化合物

生成物 1

HCID 2581921-Piperazinecarboxamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5.5 g of 3-(1-piperazinyl)-1-[4-(trifluoromethyl)phenyl]-1H-indazole, 4.8 g of nitrourea, and 80 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was collected, washed with water, and dried. The precipitate was purified on a Water's Model 500 Preparative High Pressure Liquid Chromatograph (2×) utilizing two silica gel columns and chloroform/methanol (5%) as the eluent. Concentration of the appropriate fractions yielded a solid which was recrystallized from acetonitrile to afford 2.3 g (37%) of 4-[1-(4-trifluoromethyl)phenyl)-1H-indazol-3-yl]-1-piperazine carboxamide, m.p. 138°-140°.

後処理

  1. temperaturewas heated on a steam bath for 15 minutes
  2. customthe resulting precipitate was collected
  3. washwashed with water
  4. customdried
  5. customThe precipitate was purified on a Water'
  6. customConcentration of the appropriate fractions yielded a solid which
  7. customwas recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-aad922e3ec3046acb066b31881d3ad15
出典データセット
uspto-grants-1991_03
特許番号
US04999356

関連ノート

読み込み中…