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Dimethylformamide → 4-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Nitrourea | HCID 62372 | — |
| 反応物 | 6-fluoro-1-phenyl-3-(1-piperazinyl)-1H-indazole | HCID 15117103 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide | HCID 15117104 | 73% |
反応手順
A mixture of 4.5 g of 6-fluoro-1-phenyl-3-(1-piperazinyl)-1H-indazole, 4.3 g of nitrourea, and 75 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized twice from toluene (one charcoal treatment) to yield 3.5 g (73%) of 4-(6-fluoro-1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide, m.p. 168°-170°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04999356 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-a52aa2785e414e96a9a2cf57086189c8 |
| 出典メモ | uspto-grants-1991_03 |