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Water → 4-[1-Hydroxycyclohept-1-yl-1-(imidazolyl)methyl]benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cycloheptanone | HCID 10400 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 反応物 | 4-(1-Imidazolylmethyl)benzonitrile | HCID 11148102 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-[1-Hydroxycyclohept-1-yl-1-(imidazolyl)methyl]benzonitrile | HCID 54473120 | — |
反応手順
10 g of 4-[1-(imidazolyl)methyl]benzonitrile is dissolved in 270 ml of tetrahydrofuran and combined at -50° with 40 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran, stirred for 0.5 hour at -60° combined with 6 5 g of cycloheptanone, stirred further for 1 hour, and heated to 25°. Then water is added, the mixture is diluted with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, thus producing 16 g of crude 4-[1-hydroxycyclohept-1-yl-1-(imidazolyl)methyl]benzonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411982 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-56040e84280d40dc85d916d576c7d6a0 |
| 出典メモ | uspto-grants-1995_05 |