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Water → HCID 178509719、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Cyclohexanone | HCID 7967 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 反応物 | HCID 178509721 | HCID 178509721 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 178509719 | HCID 178509719 | 94.5% |
反応手順
5 g of 4-[1-(1,2,4-triazolyl)methyl]benzonitrile is dissolved in 100 ml of tetrahydrofuran and combined at -50° with 20 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran, stirred for 0.5 hour, further agitated with 2.9 g of cyclohexanone for 1 hour at -70° and heated to 25°. Then water is added, the mixture is extracted with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, thus obtaining 7.24 g of crude 4-[1-hydroxycyclohex-1-yl-1-(1,2,4-triazolyl)methyl]benzonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411982 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-2c14748fbf5f4e2f9927f9717f486cba |
| 出典メモ | uspto-grants-1995_05 |