1-(4-Chlorophenyl)-1-octen-3-one → 1-(4-Chlorophenyl)-3-octanone

HRID 359144

反応式

HRID 359144 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:4][CH:3]=1>[Ni].C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10](=[O:16])[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 545229671-(4-Chlorophenyl)-1-octen-3-one

生成物 1

HCID 145376101-(4-Chlorophenyl)-3-octanone収率 96.4%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 1140Toluene溶媒

反応条件

温度
60 °C

実験手順

15 g of Raney nickel are added to a solution of 100 g (0.423 mol) of 1-(4-chlorophenyl)-1-octen-3-one in 500 ml of toluene and the mixture is stirred for 5 hours at 60° C. under a hydrogen pressure of 70-90 bar in an autoclave. After this the reaction mixture is filtered and concentrated under reduced pressure. 97.3 g (96.4% of theory) of 1-(4-chlorophenyl)-3-octanone are obtained in the form of a colorless oil. ##STR36##

後処理

  1. filtrationAfter this the reaction mixture is filtered
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-52fb2ce33c404f84a31b8d431707be5d
出典データセット
uspto-grants-1991_03
特許番号
US04999440

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