3-Methyl-2-buten-1-OL → Ethyl 3,3-dimethylpent-4-enoate

HRID 359164

反応式

HRID 359164 の反応式
[CH3:1][C:2]([CH3:6])=[CH:3][CH2:4]O.[C:7]([O-:13])([O-])([O:9][CH2:10][CH3:11])[CH3:8]>C1(C=CC(O)=CC=1)O>[CH3:1][C:2]([CH3:6])([CH:3]=[CH2:4])[CH2:8][C:7]([O:9][CH2:10][CH3:11])=[O:13]

参加物

4

反応物 2

HCID 111733-Methyl-2-buten-1-OLHCID 86598186Ethyl ortho-acetate2 回

生成物 1

HCID 82262Ethyl 3,3-dimethylpent-4-enoate収率 75.1%

試薬・触媒・溶媒 1

HCID 785Hydroquinone触媒

実験手順

A mixture of 12.9 g (0.15 mole) of 3-methyl-2-buten-1-ol, 48.6 g (0.3 mole) of ethyl orthoacetate and 0.5 g of hydroquinone was heated at 140° for 20 hours with stirring. Ethanol was removed by distillation during the heating. At the end of 20 hours, the mixture was distilled under reduced pressure to give, after removal of unreacted ethyl orthoacetate, 17.6 g (75% yield) of ethyl 3,3-dimethyl-4-pentenoate, b.p. 74°-78°/55 mm.

後処理

  1. temperaturewas heated at 140° for 20 hours
  2. customEthanol was removed by distillation during the heating
  3. distillationAt the end of 20 hours, the mixture was distilled under reduced pressure
  4. customto give

出典と根拠

ORDレコード
ord-975f344e2ddf41008236f96ee7ec480b
出典データセット
uspto-grants-1991_03
特許番号
US04999451

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