Ethylurea → Ethyl 2-(ethylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate

HRID 359266

反応式

HRID 359266 の反応式
[CH2:1]([NH:3][C:4]([NH2:6])=[O:5])[CH3:2].Cl[CH:8]([C:14]([C:16]([F:19])([F:18])[F:17])=O)[C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)Cl>[CH2:1]([NH:3][C:4]1[O:5][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:14]([C:16]([F:17])([F:19])[F:18])[N:6]=1)[CH3:2]

参加物

4

反応物 2

HCID 12254EthylureaHCID 2737165Ethyl 2-chloro-4,4,4-trifluoro-3-oxobutanoate

生成物 1

HCID 20064763Ethyl 2-(ethylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate収率 63.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

By the procedures of Example 4, 5.3 g (60 mmol) of ethyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 24 hours. The product mixture was treated with methylene chloride, washed with water, dried and concentrated. The residue was recrystallized from methylcyclohexane to yield 8.0 g of crystal product (m.p.=89°-90° C.) identified in Table I.

後処理

  1. washwashed with water
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was recrystallized from methylcyclohexane

出典と根拠

ORDレコード
ord-9e1e3e16ecdd485ca884f66312479be6
出典データセット
uspto-grants-1991_03
特許番号
US05000775

関連ノート

読み込み中…