Ethylurea → Ethyl 2-(ethylamino)-4-(trifluoromethyl)-5-oxazolecarboxylate
反応式
[CH2:1]([NH:3][C:4]([NH2:6])=[O:5])[CH3:2].Cl[CH:8]([C:14]([C:16]([F:19])([F:18])[F:17])=O)[C:9]([O:11][CH2:12][CH3:13])=[O:10]>C(Cl)Cl>[CH2:1]([NH:3][C:4]1[O:5][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:14]([C:16]([F:17])([F:19])[F:18])[N:6]=1)[CH3:2]参加物
4
実験手順
By the procedures of Example 4, 5.3 g (60 mmol) of ethyl urea was reacted with 10.9 g (50 mmol) of ethyl 2-chloro-4,4,4-trifluoroacetoacetate at 140°-150° C. for 24 hours. The product mixture was treated with methylene chloride, washed with water, dried and concentrated. The residue was recrystallized from methylcyclohexane to yield 8.0 g of crystal product (m.p.=89°-90° C.) identified in Table I.
後処理
- washwashed with water
- customdried
- concentrationconcentrated
- customThe residue was recrystallized from methylcyclohexane
出典と根拠
- ORDレコード
- ord-9e1e3e16ecdd485ca884f66312479be6
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US05000775
反応ノート
読み込み中…