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Nilutamide → 5,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-1-nonyl-2,4-imidazolidinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nilutamide | HCID 4493 | — |
| 反応物 | 1-Bromononane | HCID 12742 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 生成物 | 5,5-Dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-1-nonyl-2,4-imidazolidinedione | HCID 22116951 | — |
反応手順
Using the procedure of Example 1, 1 g of 1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione prepared from a 50% suspension of 170 mg of sodium hydride in oil and 0.7 ml of 1-bromo-nonane were reacted to obtain after chromatography on silica 1.08 g of the desired product melting at 63° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05411981 |
| 出典データセット | uspto-grants-1995_05 |
| ORD ID | ord-00e2339124054a4b935c76f109fac277 |
| 出典メモ | uspto-grants-1995_05 |