Hydrochloric Acid → 1-(6-Chloropyridazin-3-yl)piperidin-4-amine
反応式
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OCC)[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl>>[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([NH2:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1参加物
3
実験手順
A mixture of 6 parts of ethyl [1-(6-chloro-3-pyridazinyl)-4-piperidinyl]carbamate and 60 parts of concentrate hydrochloric acid was stirred and refluxed for 24 hours. The reaction mixture was evaporated. Water was added and the whole was treated with concentrate ammonium hydroxide. The product was extracted with trichloromethane. The extract was dried, filtered and evaporated, yielding 3.8 parts (82%) of 1-(6-chloro-3-pyridazinyl)-4-piperidinamine: mp. 260° C. (dec.) (compound 225).
後処理
- temperaturerefluxed for 24 hours
- customThe reaction mixture was evaporated
- additionWater was added
- additionthe whole was treated with concentrate ammonium hydroxide
- extractionThe product was extracted with trichloromethane
- customThe extract was dried
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-6864f4d4dfb84a81840eb42284f6bedb
- 出典データセット
- uspto-grants-1991_03
- 特許番号
- US05001125
反応ノート
読み込み中…