関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,3,4,5,6-Pentafluorobenzylidene rhodanine | HCID 4907291 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4,5,6,7-Tetrafluorobenzothiophen-2-carboxylic acid | HCID 10988683 | — |
反応手順
78 g of 2,3,4,5,6-pentafluorobenzylidene rhodanine were added in small portions to a stirred solution of 68 g of NaOH in 300 ml of water. The resultant clear red solution was heated to 90° C. for one hour, cooled in ice, acidified with concentrated HCl, and the cream coloured solid which was produced was filtered and washed. The crude product (59 g) was purified by sublimation to give 4,5,6,7-tetrafluorobenzothiophen-2-carboxylic acid having a melting point of 200° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05001163 |
|---|
| 出典データセット | uspto-grants-1991_03 |
|---|
| ORD ID | ord-6cf3f054d9ff4d0bb059e798eeecbbd0 |
|---|
| 出典メモ | uspto-grants-1991_03 |
|---|
