alpha-Chloro-m-nitrotoluene → 1-[(3-Methylbutoxy)methyl]-3-nitrobenzene

HRID 359605

反応式

HRID 359605 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Cl)([O-:3])=[O:2].[CH3:12][CH:13]([CH3:17])[CH2:14][CH2:15][OH:16].[OH-].[K+]>CN(C)C=O>[CH3:12][CH:13]([CH3:17])[CH2:14][CH2:15][O:16][CH2:7][C:6]1[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

参加物

5

反応物 3

HCID 12078alpha-Chloro-m-nitrotolueneHCID 14797Potassium HydroxideHCID 31260Isoamyl Alcohol

生成物 1

HCID 143301471-[(3-Methylbutoxy)methyl]-3-nitrobenzene

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

158.1 g (0.92 mol) of 3-nitrobenzyl chloride was dissolved in a mixture of 500 ml (4.59 mol, 5 equivalents) of 3-methyl-1-butanol and 140 ml of dimethylformamide. To the resultant mixture 78 g (1.39 mol, 1.5 equivalents) of KOH pellets were added while the mixture was being cooled in a water bath and stirred strongly. The reaction temperature was elevated to 43° C. and thereafter gradually restored to room temperature. After the mixture was stirred for 7 hours at room temperature, the reaction was completed.

後処理

  1. temperaturewas being cooled in a water bath
  2. customwas elevated to 43° C.
  3. customgradually restored to room temperature
  4. stirringAfter the mixture was stirred for 7 hours at room temperature

出典と根拠

ORDレコード
ord-d94e4fb9e1784aa0919f7629290eeb5f
出典データセット
uspto-grants-1991_03
特許番号
US05001275

関連ノート

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