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Captopril → N-(1-Naphthyl)ethylenediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Captopril | HCID 44093 | — |
| 反応物 | S-Nitrosocaptopril | HCID 129596 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 溶媒 | Acetic acid 10-acetoxymethyl-anthracen-9-ylmethyl ester | HCID 613145 | — |
| 生成物 | N-(1-Naphthyl)ethylenediamine | HCID 15107 | — |
反応手順
Typical preparations of S-nitrosocaptopril involve the reaction of 50 mM captopril with 50 mM NaNO2 in 0.1 N acetic or sulfuric acid at room temperature for five minutes, after which the reaction solution is passed over a cation exchange resin, e.g., Dowex 50 in the protonated form, and the product eluted with water. The fractions that give positive reactions with N-(1-naphthyl)ethylenediamine, after exposure to 0.15% HgCl2 and diazotization with sulfanilamide, are lyophilized. Hygroscopic, bright red crystals were obtained that were
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05002964 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-855e4ea735f84408958842a4e014961c |
| 出典メモ | uspto-grants-1991_03 |