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1-Hexanol → Dihexyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Hexanol | HCID 8103 | — |
| 反応物 | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| 反応物 | (2S-trans)-18-Carboxy-20-(carboxymethyl)-13-ethyl-2,3-dihydro-3,7,12,17-tetramethyl-8-vinyl-21H,23H-porphine-2-propionic acid; (17S,18S)-18-(2-Carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid | HCID 138978174 | — |
| 反応物 | HCID 178435490 | HCID 178435490 | — |
| 生成物 | Dihexyl ether | HCID 8198 | 68% |
反応手順
The chlorin-e6 tetramethyl ester prepared in Example 2 (50 mg) was reacted with HBr/acetic acid and n-hexyl alcohol as described in Example 1 for methyl pheophorbide. The desired product was isolated in 68% yield, and the purity confirmed by TLC and HPLC. The structure was confirmed by NMR and mass spectroscopy; the spectra also showed evidence for aggregation of two chlorin units.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05002962 |
| 出典データセット | uspto-grants-1991_03 |
| ORD ID | ord-c5e0e9607d044cb39ffdf4aee866d473 |
| 出典メモ | uspto-grants-1991_03 |