Hydrochloric Acid → 2-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride

HRID 359831ノート

反応式

HRID 359831 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[CH:7][CH:8]=1.[CH3:11][C:12](=[N:16][OH:17])[C:13](=O)[CH3:14].[ClH:18]>C(O)(=O)C>[ClH:18].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:13]([CH3:14])=[C:12]([CH3:11])[N+:16]=2[O-:17])=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312444-MethoxybenzaldehydeHCID 63989692-Oxime 2,3-butanedione

生成物 1

HCID 200640232-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 68.07 g of anisaldehyde, 50.5 g of 2,3-butanedione mono-oxime and 150 ml of acetic acid was saturated with hydrogen chloride gas and the mixture was allowed to stand at room temperature for 3 hours. The solid product was collected and recrystallized from methanol to give 2-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride, m.p. 194°-196° C. The latter was converted to the free base for use in the next reaction by treatment with sodium bicarbonate solution.

後処理

  1. customThe solid product was collected
  2. customrecrystallized from methanol

出典と根拠

ORDレコード
ord-b36a4cf35ab744a888817db0b69406a2
出典データセット
uspto-grants-1991_03
特許番号
US05002960

反応ノート

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